Chemical resistant gloves protect your hands from solvents and isocyanates when mixing paints, spraying paint, and cleaning painting equipment. When these chemicals touch your skin, they can irritate or burn the skin or cause an allergic reaction. They may also pass right through the skin and cause harm to other parts of your body, just as if you inhaled them.
MSDSs commonly call for “impervious gloves” to protect the hands when working with solvents. This statement is not very helpful and is a bit misleading. Gloves that are not resistant to a particular solvent will allow the solvent to pass through in just seconds. Even the most resistant glove will eventually allow the solvent to pass through and contaminate your skin. It is simply a matter of time. Solvents can also severely degrade gloves, causing them to deform and fall apart. Similar problems exist for isocyanates.
To prevent skin exposure, you must select a glove that is sufficiently resistant to the solvent or isocyanate to prevent it from passing through while you are wearing the glove. All gloves must be replaced periodically.